INCREASED FREQUENCY OF MICROALBUMINURIA IN PATIENTS RECEIVING STATINS
It has been shown that hidroxi-metil-glutaril-CoA
inhibitors, also called statins, may interfere with the tubular reabsorption of
albumin, increasing urinary albumin excretion. We have performed an observational, cross sectional, descriptive study on patients attended at primary care settings. The prevalence of microalbuminuria was 6.9% for those
patients who were not taking statins vs. 15.0% for those one receiving statin treatment
(p=0.001; X2 test). Odds-ratio was 2.59 (without statins, 0.62; with
statins 1.48; p = 0.002). Patients treated with atorvastatin and simvastatin
were compared (the number of patients taking other statins was too small): 27.1%
of patients taking atorvastatin showed microalbuminuria vs. 12.3% of subjects
taking simvastatin (p = 0.012), the OR was 0.38 (simvastatin 0.60; atorvastatin
1.59, p = 0.022). Logistic regression analysis showed an independent
relationship between statin treatment and microalbuminuria in diabetic patients.
Statin treatment seems to be associated to abnormal urinary albumin excretion.
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